Welcome PC/PCol 123

The materials you are responsible for are listed below.  I would of course encourage you to browse through the other topics under Drug Therapies, including the 3 drug approvals  in 2017 and 2018 (Safinamide/Xadago and two new extended-release formulations of amantadine).

Physiological Basis of Parkinson’s

What is dopamine and what does it have to do with Parkinson’s disease?
Where does dopamine come from?
What happens to dopamine after it is made?
Why do the dopamine producing cells die?
Is Parkinson’s disease genetic?

Drug Therapies

Intro to levodopa
Why must patients take levodopa so frequently?
What are the major side effects of levodopa?
Intro to MAO-B inhibitors
Intro to dopamine agonists
Nuplazid for Parkinson’s psychosis
Droxidopa for orthostatic hypotension